摘要
目的建立高效液相色谱法(HPLC法)测定西咪替丁片的含量。方法采用KromasilC18柱(250mm×4.6mm,5μm)色谱柱,以甲醇-水(40∶60)为流动相,检测波长为218nm。结果西咪替丁浓度线性范围是3.2～40.4μg/mL(r=0.9999),平均回收率为99.2%,RSD=1.1%(n=6)。结论HPLC法快速、简便、准确。
Objective To determine the content of cimitidine in cimitidine tablets by HPLC. Methods Kromasil C18 （250 mm×4.6 mm, 5μm） column was used. The mobile phase consisted of methanol-water （40：60） and the detective wavelength was 218 nm. Results The linear range was 3.2-40.41μg/mL（r=0.9999）.The average.recovery rate was 99.2%, RSD=1.1% （n=6）.Conclusion The method is rapid, simple and accurate.
出处
《中国药业》
CAS
2006年第12期15-16,共2页
China Pharmaceuticals
