CQD人工腱修复兔跟腱的组织学观察

Histological Observation of CQD Artificial Tendon Applied in Repairing Rabbit's Tendon

目的应用CQD人工腱修复兔跟腱,以期研究其组织形态学的改变。方法随机选择实验兔一侧后肢作为实验侧,游离跟腱并切除中间束,CQD人工腱替代缺损部,编织缝合于正常肌腱的上下端,生物膜将CQD人工腱包好,全层缝合皮肤。另一侧后肢作为对照侧,除不用生物膜包裹人工腱体外,手术方法与实验组相同。随机分为2周1、、23、、4个月组,每组4只,自身对照。观察指标有:一般情况、大体标本观察、组织学观察、超微结构观察。结果一般情况:术后动物活动不受限,无局部感染,10天后伤口愈合,缝线自然脱落。但从组织学、电镜的观察实验组的愈合均较对照组提前。结论CQD人工腱能够在动物体内腱化并替代肌腱,这将为临床应用提供新的人工腱采料。

Objective To study the histomorphological change of CQD artificial tendon applied in repairing rabbit＇s tendon. Methods The posterior limbs on one side of the rabbit were selected, the tendons were freed and the intermediate bands were removed, and then CQD artificial tendons were applied to replace the defective parts and sutured on the normal tendons, the biological membrane wrapped up the artificial tendons and the skin was sutured. The other side posterior limbs were the control;the operation method was same except that the artificial tendons were not wrapped up by the biological membrane. Observation was made 2 weeks, 1 m,2m, 3m,4m after operation. Results The activities were not limited, and no local infection occurred, the cut healed 10 days later;the histological and electron microscopic observation showed that the healing was ahead of that of the control. Conclusions CQD artificial tendon can replace the tendons in animal, which will provide the new material for artificial tendons in clinical application.