小鼠烧伤应激影响鼠尾皮肤增殖和角化的形态学观察

Morphological Observation of the Effect of the Burn Stress to the Skin in Tail of Mice

目的观察烧伤应激对小鼠鼠尾皮肤的影响,探索应激在银屑病发病中作用。方法在鼠背制作2cm×1cm的烧伤创面,于烧伤后1h、24h、1w、2w、4w分别取鼠尾皮肤观察表皮的增殖和角化情况。结果与正常小鼠鼠尾皮肤对照,烧伤应激后1w、2w、4w,鼠尾皮肤角质形成细胞(KC)明显增殖,角化过度和角化不良,4w时最明显。结论烧伤应激可促进小鼠鼠尾皮肤KC增殖、角化过度和角化不全。

Objective To observe the effect of the burn stress to the skin in tail of mice and to study the function of stress in psoriasis pathogenesis. Methods The burn surface with 2cm × 1cm was made on the back of mice and the thing of keratinocyte （ KC ） proliferation and keratosis of the skin in tail of mice were observed 1 h, 24h, 1w, 2w and 4w after burn. Results Compared with the skin in tail of normal mice, after burn stress 1 w, 2w and 4w, KC proliferated obviously, scarfskin had hyperkeratosis and parakeratosis, which were most prominent in 4w. Conclusions The burn stress can promote KC proliferation, scarfskin heperkeratosis and parakeratosis.