慢性肺心病并发多器官衰竭(MOF)患者NF-κB活性的变化及其临床意义

Change of Nuclear Factor Kappa B Activity in Patients with Chronic Pulmonary Heart Disease Accompanied Multiple Organ Failure and Its Clinical Significance

为观察慢性肺心病并发多器官衰竭(MOF)患者外周血单核细胞(PBMC)中核因子κB(NF-κB)活性的变化及其在慢性肺心病并发MOF的作用,将30例慢性肺心病并发MOF患者作为观察组,同时选择30例无MOF的慢性肺心病患者作为对照组结论显示慢性肺心病并发MOF患者PBMC中NF-κB的活性显著增高,NF-κB活化后上调TNF-α、IL-6等的表达在MOF的发生、发展过程中起着重要作用。

To determine the nuclear factor kappa B（NF-κB） activity in peripheral blood mononuclear celIs（PBMC） and its role in patients with chronic pulmonary heart disease accompanied multiple organ failure. Thirty patients with chronic pulmonary heart disease accompanied multiple organ failure were selected as experimental group, other thirty patients with chronic pulmonary heart disease without multiple organ failure were selected as control group. NF - κB activation in PBMC in patients with chronic pulmonary heart disease accompanied multiple organ failure obviously increase, after the NF- κB were activated, it up- regulates the expression of TNF- α and IL - 6, and it may be a major mechanism of MOF.