精神分裂症遗传学研究的理性思辨

Philosophical Thinking of Schizophrenia Genetic Study

精神分裂症是一种常见的重性精神障碍,属于复杂的多基因遗传性疾病。随着分子生物学技术和遗传学数据分析方法的进步,精神分裂症易感基因方面的研究取得了一定的进展,但是至今还没有一个精神分裂症的易感基因得到准确定位。系统生物学是采用系统科学的方法研究一个生物系统的一种大科学,为寻找精神分裂症等复杂疾病的易感基因提供一种新的思路。

Schizophrenia is a severe neuropsychiatric disorder with a polygenic mode of inheritance. Along with the improvement of molecular biologic technologies and genetic analysis, remarkable progress made in the past several years. But until today, there is still no candidate gene has been confirmed. System biology, which use systematic science principal to explore the whole system, can provide a new approach to study the genetic causes of schizophrenia.