微波辐射催化下一步合成红霉胺衍生物

One-pot Synthesis of Erythromycylamine Derivatives under Microwave Irradiation

目的:寻找合成红霉胺衍生物的简便方法。方法:以红霉素A和相应的胺在微波辐射条件下,利用Leuckart反应一步合成目标化合物。结果:合成了6个红霉胺衍生物,其结构均经IR、ESI-MS及13C-NMR确证。结论:微波辐射催化下一步合成红霉胺衍生物,方法简单、有效。

Objective： To explore a more convenient method of synthesis of erythromycylamine derivatives. Method： The target compounds were one-pot synthesized from EMA and amines under the microwave irradiation condition through the Leuckark reaction. Result： Six compounds were synthesized, their structures were confirmed by IR, ESI-MS and 13 C-NMR. Conclusion： The one-pot synthesis method of erythromycylamine derivatives under microwave irradiation is proved to be more convenient and effective.