摘要
目的:寻找合成红霉胺衍生物的简便方法。方法:以红霉素A和相应的胺在微波辐射条件下,利用Leuckart反应一步合成目标化合物。结果:合成了6个红霉胺衍生物,其结构均经IR、ESI-MS及13C-NMR确证。结论:微波辐射催化下一步合成红霉胺衍生物,方法简单、有效。
Objective: To explore a more convenient method of synthesis of erythromycylamine derivatives. Method: The target compounds were one-pot synthesized from EMA and amines under the microwave irradiation condition through the Leuckark reaction. Result: Six compounds were synthesized, their structures were confirmed by IR, ESI-MS and 13 C-NMR. Conclusion: The one-pot synthesis method of erythromycylamine derivatives under microwave irradiation is proved to be more convenient and effective.
出处
《中国药师》
CAS
2006年第8期694-697,共4页
China Pharmacist