喷昔洛韦凝胶中不同促渗剂对透皮作用的影响

Comparison of Absorption Promoter's Effect on Penciclovir Gel

目的:考察聚山梨酯80(Tw80)、丙二醇(PG)作为单一促渗剂和二元促渗剂对喷昔洛韦凝胶体外透皮作用的影响。方法:选用直立式Franz扩散池,以离体鼠皮为屏障,分别采用10％PG,10％PG+1％Tw80,20％PG+1％Tw80为促渗剂,HPLC测定接受液中喷昔洛韦的含量,计算药物累积渗透量。结果:Tw80可促进喷昔洛韦的透皮吸收,不同浓度PG对喷昔洛韦的透皮吸收影响较小。结论:促渗剂Tw80与PG联用效果更佳。

Objective： To study the influence of polysorbate 80 （Tw80） and propylene glycol （PG） as absorption promoters on penciclovir gel absorption. Method： accumulated absorbed drug per unit area with 10% PG, 10% PG ＋ 1% Tw80, 20% PG ＋ 1% Tw80 as absorption promoters were Determined, the two-cell diffused pool with mouse skin as the barrier was used. Result： Tw80 could enhance transdermal absorption of penciclovir gel, PG had litter effect on absorption. Conclusion： The co-application of Tw80 and PG can enhance absorption more significantly.