奥硝唑三联疗法治疗Hp相关溃疡病的临床研究

Clinical Study of Omidazole Triple Therapy in H. pylori Related Peptic Ulcer

目的:评价奥硝唑三联疗法治疗幽门螺杆菌(Hp)相关的消化性溃疡病的疗效及其安全性。方法:将Hp检测阳性,内镜检查为活动期十二指肠溃疡的患者分为治疗组:雷贝拉唑,克拉霉素,奥硝唑;对照组:雷贝拉唑,克拉霉素,替硝唑;连用1周。然后两组继续使用雷贝拉唑1周。第28天复查内镜并检测Hp。结果:疗程结束后第28天内镜检查结果和Hp检测结果两组对比无统计学差异。结论:雷贝拉唑、克拉霉素、奥硝唑三联疗法对Hp相关的消化性溃疡病具有良好的治疗作用和安全性。

Objective： To evaluate the efficacy and safety of omidazole triple therapy on the H. pylori related peptic ulcer. Method： The patients with H. pylori infection and active duodenal ulcer were divided into two groups ：the therapeutic group were treated with omidazole, clarithromycin and rabeprazole for one week while the controlled group were treated with tinidazole, clarithromycin and rabeprazole for one week, then two groups were treated with rabeprazole only for another one week. Repeated endoscopy and H. pylori were checked 28 days after therapy. Result： There was no statistic difference of H. pylori eradication and repeat endoscopy 28 days after therapy were finished between two groups. Conclusion： The triple therapy of rabeprazole, clarithromycin, omidazole is effective and safety in treating the H. pylori related peptic ulcer.