妊娠期肝内胆汁淤积症患者瘙痒情况与围生儿结局

Relationship between maternal pruritus and outcome of perinatal-fetus in intrahepatic cholestasis of pregnancy

目的探讨妊娠期肝内胆汁淤积症(ICP)患者瘙痒情况与围生儿结局的关系。方法对84例有完整病史及分娩记录的ICP患者的临床资料进行回顾性分析。结果瘙痒症状发生早、分娩前瘙痒症状持续时间长者中胆汁酸、胆红素同时升高的比例增加,胆汁酸、胆红素值升高;羊水胎粪污染发生率、早产率、新生儿窒息发生率增加,差异有显著性(P<0.05)。结论ICP患者瘙痒情况与胆汁酸、胆红素的改变及围生儿结局有一定的关系,医、患均需高度重视,早发现、早诊断、早治疗,适时终止妊娠,改善围生儿预后。

Objective To investigate the relationship between maternal pruritus and outcome of perinatal-fetus in intrahepatic cholestasis of pregnancy （ ICP）. Methods Clinical data of 84 cases with complete history and delivery record were retrospectively analyzed. Results Both bile acid and bihrubin increased in the patients whose pruritus occurred early in pregnancy and persisted for a long time and; the incidence of meconium, premature delivery and asphyxia neonatorum were also increased,with significant difference （ P 〈 0.05 ）. Conclusion The pruritus of ICP patients is related to the changes of bile acid and bihrubin as well as the outcome of perinatal-fetus. Early diagnosis and treatment as well as timely termination of pregnancy may improve the prognosis of fetuses.