叶酸干预对老年高血压患者血管内皮功能的影响

Effect of Folic Acid on Endothelial Function in Elderly Hypertensive Patients

目的探讨叶酸对老年高血压患者血管内皮功能的影响。方法42例轻、中度老年高血压患者,随机分为叶酸干预组22例,对照组20例。采用高分辨率超声检测治疗前及治疗12周后肱动脉血流介导的血管内皮依赖性舒张功能与硝酸甘油介导的非内皮依赖性舒张功能。结果治疗前后两组间及组内肱动脉基础内径差异无统计学意义,叶酸干预治疗12周后与治疗前和对照组比较肱动脉血流介导的血管内皮依赖性舒张功能(11.59%±4.79%比7.15%±3.20%和8.14%±3.01%)、肱动脉硝酸甘油介导的非内皮依赖性舒张功能(19.73%±5.80%比16.69%±4.75%和17.55%±6.05%)均有明显改善(P<0.05)。结论叶酸对老年高血压患者血管内皮功能损害有一定的改善作用。

To evaluate the effect of oral folio acid on endothelial function in eldedy hypertensive patients. Methods Fourty-two elderly patients with mild essential hypertension were divided with randomized principle into two groups： folic acid administrative group （ n = 22） and control group （ n = 20）. Flow-medicated dilatation （ endothelium dependent） and nitroglycerin-induced dilatation （endothelium independent） using high-resolution ultrasound were measured before and 12 weeks after treatment. Results The difference of baseline diameter （D0） in the two groups were not statistically significant before and after treatment. Flow-mediated dilatation of patients with folic acid administration group （ 11.59% ± 4.79% ） was improved significantly compared with that of pretherapy（7.15%±3.20%） andcontrolgroup（8.14%±3.01%） （P〈0.05）. Endetheliurn-independent dilation （19.73% ± 5.80% ） also was improved significantly compared with that of pretherapy （16.69% ± 4. 75%） and control group （17.55%±6.05%） （P〈0.05）. Conclusion Fohc acid administration improves arterialendothelial function in elderly hypertensive patients.