不同药物联合治疗带状疱疹的疗效比较

A Comparative Study on Efficacy of Different Drug Combinations in Shingles

目的:比较不同药物匹配在治疗带状疱疹中的疗效。方法:采用t检验法,对照观察4组带状疱疹患者的临床疗效。结果:病毒唑组与阿昔洛韦组相比各项疗效P值均<0.05,差异有显著性;病毒唑组与病毒唑+氯氧油组相比各项疗效P值均<0.05,差异有显著性;阿昔洛韦组与阿昔洛韦+氯氧油组相比各项疗效P值均<0.05,差异有显著性;病毒唑+氯氧油组与阿昔洛韦+氯氧油组相比各项疗效P值均<0.05,差异有显著性。结论:抗病毒药物(病毒唑或阿昔洛韦)和氯氧油联合使用与单独使用抗病毒药物(病毒唑或阿昔洛韦)相比,疗效显著提高(P<0.05);两种药物联合治疗(病毒唑+氯氧油和阿昔洛韦+氯氧油)之间,又以阿昔洛韦+氯氧有的疗效好(P<0.05)。

Objective：To compare the efficacy of different drug combinations in shingles. Methods. the efficacy in four groups of patients with shingles was analyzed by t test. Results ： the P value in comparison of efficacy measures between ribavirin and acyclovir groups was less than 0.05 at a level of statistical significance. Comparisons of efficacy measures between ribavirin alone and ribavirin ＋ CZC oil （mixture of chloramphenicol, zinc oxide, castor oil and peanut oil）, acyclovir alone and acyclovir ＋ CZC oil, ribavirin ＋ CZC oil and acyclovir ＋ CZC oil also showed significant differences with P 〈 0.05. Conclusion： Combined therapy with an antiviral （either ribavirin or acyclovir） and CZC oil resulted in improved efficacy as compared with antiviral alone （ P 〈 0.05 ）. When drug combinations were concerned, Acyclovir ＋ CZC oil showed more benefits as compared with ribavirin ＋ CZC oil （P 〈 0.05）.