有氧锻炼结合饮食控制减体重对肥胖者血抵抗素及心血管疾病危险因素的影响

The Effects of Weight Reduction on Resistin and Cardiovascular Risk Factors in Obese Persons

目的:观察通过运动锻炼和饮食控制减体重,对肥胖者血抵抗素及心血管疾病危险因素的影响。方法:对44名肥胖者采取6周封闭管理形式集中减肥,严格控制饮食,进行运动训练。减重前后采用酶联免疫法测定空腹血抵抗素,同时测定血胰岛素、血脂、血糖等指标。在减体重过程中,受试者每2周测定一次体重、腰臀围比、体成分和血压等。结果:通过6周减体重,肥胖者血清抵抗素水平明显降低,多元线性回归分析显示,减重前后心率的差值成为影响减重前后抵抗素水平差值的重要因素。减重后,受试者腰围、臀围、腰臀围比、体脂含量及百分比、静息血压较减重前显著降低(P<0.001);血清总胆固醇、甘油三酯、低密度脂蛋白胆固醇、胰岛素及胰岛素抵抗指数等心血管疾病危险因素相关指标较减重前亦明显下降(P<0.001)。结论:采取运动锻炼结合饮食控制的方法减轻肥胖者体重,可有效降低其血抵抗素水平及心血管系统疾病的危险因素。

Objective To observe the effects of weight reduction on resistin and cardiovascular risk factors in obese persons by exercise and energy intake controlling. Methods An organized , closed program with exercise and energy intake controlling for 6 weeks was taken in 44 obese subjects for weight reduction. Fasting serum resistin was measured by enzyme - linked immunosorbent assay before and after weight reduction. At the same time, serum insulin, lipids, and glucose were examined. Weight, waist circumference, hip circumference, body component, and rest blood pressure were measured every 2 weeks. Results After 6 weeks weight reduction, the serum resistin was decreased significantly. The difference of heart rate before and after weight reduction was the only important factor that affected the change of resistin before and after weight reduction, showed by the multiple linear regression analysis. The weight, body mass index, waist circumference, hip circumference, waist hip ratio, fat mass and body fat percentage, rest blood pressure of the subjects were diminished significantly（ P 〈 0. 001 ）. The marked decreases were found in serum total cholesterol, triglyceride, low density lipoprotein cholesterol, insulin and in insulin resistance index （P 〈 0.001 ）. Conclusion The serum resistin level can be efficiently decreased and the cardiovascular risk factors can be attenuated by exercise - and diet controlling- induced weight reduction in obese people..