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颅脑外伤后局部脑组织HSP70基因的表达 被引量:9

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摘要 当今对于颅脑外伤后神经细胞热休克蛋白70(HSP70)基因的表达己有许多文献报道,但多数研究是在脑外伤动物模型上进行的,迄今国内尚未见直接检测人颅脑外伤后HSP70基因表达的报道。笔者旨在检测颅脑损伤患者损伤局部脑组织神经细胞中HSP70基因的表达,并初步探讨其临床意义。
出处 《中华创伤杂志》 CAS CSCD 北大核心 2006年第8期623-624,共2页 Chinese Journal of Trauma
基金 福建省教育厅科研基金(JB00132)
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参考文献4

  • 1闫东明,张志强,宋来君,冯祖荫,徐国本,保建基.右美沙芬治疗对兔急性脑外伤保护作用的研究[J].中华创伤杂志,2002,18(10):596-598. 被引量:4
  • 2Dutcher SA, Underwood BD, Walker PD, et al. Patterns of heat - shock protein 70 biosynthesis following human traumatic brain injury. J Neurotrauma, 1998, 15:411 -420.
  • 3Burdon RH. Heat shock proteins in relation to medicine. Mol Aspects Med, 1993, 14:83- 165.
  • 4Sato S, Abe K, Kanagoc J, et al. Isolation of complementary DNAs for heat shock protein (HSP) 70 and heat shock cognate protein(HSC)70 genes and the expressions in postischaemic gerbil brain. Neurol Res, 1992,14:375 - 380.

二级参考文献6

  • 1Ferichs KU, Lindsberg PJ, Hallenbeck JM, et al. Platelet-activating factor and progressive brain damage following focal brain injury. J Neurosurg, 1990, 73:223-233.
  • 2Hoshino S. The findings indicate that HSP70 expression is closely related to ischemia brain injury and that HSP70 expression is not related either breakdown of the blood-brain barrier or reactive anxonal changes.Nippon Ika Daigaku Zasshi, 1995, 62:55-64.
  • 3Schlesinger MJ. Interaction of HSP70 with newly synthesized proteins: implications for protein folding and assembly. J Physiol, 1993, 264:33-36.
  • 4Nowak Ts Jr. Synthesis of heat shock stress proteins during cellular injury. Ann N Y Acad Sci, 1993, 679:142-156.
  • 5Van Rijen PC, Verheul HB, van Echteld CJ, et al. Effects of dextromethorphan on rat brain during ischemia and reperfusion assessed by magnetic resonance spectroscopy. Stroke, 1991, 22:343-350.
  • 6Albers GW, Saenz RE, James JA Jr, et al. Safety and tolerance of oral dextromethorphan in patients for brain ischemia. Stroke, 1991, 22: 1075-1077.

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