蛇床子素抗心律失常作用实验研究

Experimental Studies on the Anti-arrhythmic Effects of Osthol

蛇床子素（ＯＳＴ）对氯仿诱发的小鼠室颤、氯化钙诱发的大鼠室颤均有明显的预防作用，对乌头碱诱发的大鼠心律失常有明显的治疗效果，且能明显提高兔心室电致颤阈。这些结果均表明ＯＳＴ有抗心律失常作用，并提示其以钠、钙通道有一定的阻断作用。ＯＳＴ的小鼠ｉｖＬＤ５０为类６５．２ｍｇ．ＫＧ^（－１）

Osthol(Ost) was not Only effective in preventing ventricular fiblillation induecd by chloroform in mice and by calcium chloride in rats, but was effective in treatin arrhythmia induced by aconitine in rats.Furthermore,Ost raised the threthold of ventricular fiblillation induced by electrical stimulation in rabbits. These results indicated that Ost exhibited anti-arrhythmic effects by blocking Na+Ca(2+) channels to a certain extent. The acute LD50 Of Ost in mice is iv 65.2 mg·Kg(-1).