育子丸治疗大鼠雄性不育

Study of yuziwan in the treatment male rat sterility model

目的研究育子丸治疗雄性不育大鼠模型的效果。方法观察雄性不育大鼠模型用育子丸治疗后生育能力、精液、性激素、精核蛋白的变化情况。结果育子丸治疗后,受孕率高于模型组,差异有统计学意义(P<0.01);4组FSH比较,差异无统计学意义(P>0.05),模型组LH、T值均比正常组显著下降,差异有统计学意义(P<0.01),治疗1、2组LH、T值均比模型组显著升高,差异有统计学意义(P<0.01);4组精子密度、精子活率及A组精子数比较,差异有统计学意义(P<0.01)。模型组精子质量比正常组显著降低,治疗1组各项指标均显著高于模型组,治疗2组精子计数及活力显著高于模型组,差异有统计学意义(P<0.01)。治疗后各组TH相对含量、RP相对含量及TH/RP比较,差异有统计学意义(P<0.01)。大鼠RP含量提高,精核蛋白构成改善,TH/RP比例下降,与模型组比较,差异有统计学意义(P<0.01)。结论育子丸在改善异常的精核蛋白及其构成等方面具有显著的疗效,同时提高精子数量、活率及精子活力,提高生育力,改善内分泌功能对治疗雄性不育大鼠具有良好疗效。

Objective To study the effect of yuziwan, a mixture of Chinese herbs, in the treatment of male rat sterility model. Methods To observe the changes in reproduction ability, protamine, semen and sex hormone of male rat sterility model treated with yuziwan. Results Rats treated with Yuziwan showed improvement in protamine, sperm quality, reproduction ability and endocrine function. Conclusion Yuiwan have curative effect in the treatment of male rat sterility.