口服二巯基丙磺酸钠驱汞试验的研究

Study on the Oral DMPS Provocative Test for Mercury

使用ＤＭＰＳ（一次口服３００ｍｇ）对龋齿充填者、口腔科技师和医师以及含汞皮肤洗剂生产和使用者共５组不同的汞接触人群以及相应的３个对照组进行了驱汞试验。分别收集投药前６小时和投药后６小时的全部尿样，用冷原子发生器原子吸收分光光度法测定尿汞含量。结果显示５组接汞人群无论投药前或投药后，尿汞均值均明显地高于相应的对照组；自身比较，服药后６小时尿汞排泄量也均显著增加。５组接汞人群用药后尿汞排泄比投药前分别增加了２４、８７、４８、４４和８６倍；相应的３个对照组也分别增加了１８、３４和３７倍。结果提示，口服ＤＭＰＳ是一种很好的驱汞方法，有助于汞中毒的预防、诊断和治疗。

The DMPS provocative test(300mg p.o.)for mercury was given to five different groups exposed to mercury,persons with dental amalgams,dental technicians,dentists,skin lotion makers and skin lotion users,and three corresponding control groups.Urine samples of 6 hours before and 6 hours after DMPS administration were collected and the urinary mercury levels were determined by cold vapor atomic absorption spectrophotometry,The results indicated that the mean urinary mercury levels in the five groups exposed to mercury were significantly higher than those of corresponding referent groups both before and after DMPS administration.The mean urinary mercury values excreted within 6 hours after DMPS were also increased significantly in all groups compared with those before DMPS administration.The administration of the DMPS provocation in five groups exposed to mercury resulted in 24,87,48,44 and 86-fold increase,respectively,of 6 hour urinary mercury compared with those during the 6 hour period before the administration of this chelating agent.The increase in urinary mercury from the DMPS provocative test was 18,24 and 37-fold in the three corresponding referent groups respectively.The results suggested that the oral administration of DMPS was a good measure for the removal of mercury from the body and it was very helpful to the prevention,diagnosis and treatment of mercury poisonlng.