摘要
70例血清总胆固醇在6.5~7.8mmol/L的患者随机分为A、B两组,分别服用美降之10mg/d和20mg/d治疗3个月。结果显示A、B两组降低血清总胆固醇、低密度脂蛋白胆固醇、载脂蛋白B和升高高密度脂蛋白胆固醇明显(分别为P<0.01和P<0.05),且作用相似(分别P>0.05);也能升高载脂蛋白A-I(P均<0.01),但第2个月B组较A组明显(P<0.01);B组第3个月甘油三酯也有明显下降(P<0.05)。两种不同剂量美降之均未见明显不良反应。
patients with a total cholesterol level of 6.5 to 7.8 mmol/L were randomly divided to receive 10 mg daily dose and 20 mg daily dose of lovastatin for three months.Results showed that in both groups the serum TC,LDL C,apo B were reduced,and serum HDL C and apo A I were significantly increased but the changes were more pronounced in 20 mg daily dose group in the second month and serum TG was significantly reduced in the 20 mg daily dose group in the third month.No side effects were observed in both groups.
出处
《中国新药杂志》
CAS
CSCD
1996年第5期357-359,共3页
Chinese Journal of New Drugs