血清瘦素与老年冠心病患者及其危险因素的关系

The relationship between serum leptin and elderly patients with coronary heart disease

目的研究血清瘦素(LEP)与老年冠心病患者的关系。方法检测45例老年冠心病患者(冠心病组)和47例健康对照者(对照组)的空腹LEP、瘦素受体(LEPR)、空腹血糖(FBG)以及血脂、身高、体重、C反应蛋白(CRP)等指标,其中LEPR、LEP用酶联免疫检测法。分析LEP、LEPR、CRP及血脂与冠心病的关系。结果冠心病组LEP、CRP、血压明显高于对照组,而LEPR水平明显低于对照组(P<0.05或0.01.)。LEP与腰臀比值、甘油三酯、胆固醇、舒张压、收缩压、CRP呈正相关,与LEPR、高密度脂蛋白呈负相关(P<0.05)。结论LEP水平升高可能与冠心病的发病密切相关。

Objective To investigate the relationship between serum leptin （LEP） and elderly patients with coronary heart disease（CHD）.Methods LEP, LEPR, TC, TG, HDL, LDL, FBG, CRP, SBP and DBP were detennined in 45 elderly patients with coronary heart disease and 47 healthy persons as control group. Serum LEP and LEPR levels were measured by enzyme-linked immunosorbent assay （ELISA）. The relationships between LEP, LEPR, CRP, dyslipidemia and coronary heart disease were analyzed. Results The patients had significantly higher LEP, CRP, DBP, SBP, but lower LEPR and HDL （ P 〈 0.05 or P 〈 0.01） than the control group. LEP was positively correlated with BMI, TC, TG, DBP, SBP and CRP, and negatively correlated with LEPR and HDL. Conclusion The results suggest that hyperleptinemia is a significant risk factor for elderly individuals with CHD.