干扰素对各型慢性乙型肝炎的细胞免疫功能上调作用

Upregulation of interferon to the cell immunity in each chronic B hepatitis

目的 抗病毒药物干扰素和贺普丁与细胞免疫的关系。方法 用流式细胞仪检测慢性乙型肝炎外周血淋巴细胞方法，比较各型慢性乙型肝炎148例与正常对照组的关系，抗病毒药物干扰素20例和贺普丁49例治疗后细胞免疫的变化。结果 贺普丁治疗6mo后慢性乙型肝炎病人CD4^＋、CD8^＋绝对值、CD4^＋／CD8^＋比值均与未使用组相近，差异无显著性（P〉0．05）；干扰素治疗6mo后的CD4^＋、CD8^＋绝对值比未使用组高，差异有显著性（P〈0．05）。结论 各型慢性乙型肝炎存在细胞免疫的紊乱，干扰素有调节细胞免疫功能作用。

Objective Interferon and lamivudine are antiviral drugs with function of upregulation cellular immunity. Methods Flow cytometry was applied into peripheral blood lymphoid cell counting of each type chronic hepatitis B patients and 148 normal control. Cell immunity was documented of 20 cases of treatment with interferon and 49 cases with lamivudine. Results There was no significantly difference of value of CD4^＋, CD8^＋ and CD4^＋/CD8^＋ between lamivudine group and control after 6 mon of therapy （P〉0.05）. Value of CD4^＋, CD8^＋ were significantly higher in interferon group than that in control after 6 mon treatment （P〈0.05）, Conclusion Each type of chronic hepatitis B exists dysfunction in cell immunity. The interferon could regulate the cell immunity.