经血途径传播慢性丙型肝炎病人临床流行病学分析

Epidemiological investigation of 62 blood transmitted Chronic Hepatitis C patients

目的 探讨体检发现并诊断为丙型肝炎病人的临床流行病学特点。方法 对62例病人进行书面问卷调查并分析年龄、性别、临床表现和肝功能、肝纤维化指标等。结果 62例病人都有接受输血、血制品以及血液透析治疗的病史。60例的HCV-RNA几何均数为10^5copies／mL。慢性肝炎轻度有19例（30．6％），中度有25例（40．3％），重度有18例（29．0％），3例伴有肝硬化。结论 75％无自觉症状的丙型肝炎病人其肝功能受损比较明显，对接受过输血、使用血制品或是进行透析治疗的高危病人有必要进行抗-HCV的检测，以便及时发现是否感染丙型肝炎病毒。

Objective To understand the epidemiological characteristics of CHC （Chronic Hepatitis C） sufferers which are diagnosed through medical examination. Methods To analyze all the patients （62 samples） in age and gender; make statistical analysis for the lab results; and also carry out a questionnaire method to all patients. Results 32 males and 30 females, all have got blood transfusion, received blood preparation, accepted hemodialysis or mix. Total 62 patients are anti-HCV positive. 60 are HCV-RNA positive and the geometric mean （Gm） value is 105copies/ml. According to the result of ultrasound examination of liver, 30.6% （19samples） has mild degree, 40.3% （25samples） has moderate degree, 29.0% （18samples） has serious degree changes. And 3 have hepatic cirrhosis in total. Conclusions The liver damage is conspicuous on CHC sufferers without subjective symptom. For the patients got blood transfusion, blood preparation or hemodialysis in half or one year, it is necessary to carry out hepatic function detection especially the anti -HCV in order to discover HCV infection in time.