湖北地区乙型肝炎病毒基因分布的临床意义

The Clinic Significance of the Genotype Distributing of Hepatitis B in Hubei Province

目的 探讨湖北地区乙型肝炎病毒基因型分布与临床的相关性。方法 选取我院2003年至2005年门诊血清HBVDNA阳性病人390例，其中乙型肝炎表面抗原（HBsAg）携带者120例，慢性乙型肝炎（CHB）180例，急性肝炎（AH）15例，肝炎肝硬化（HC）75例，分别测定各型肝炎病人的基因型分布。结果 乙型肝炎病程／〉5年与〈5年的病人中HBVC基因型感染者分别为：20．9％（10／46）、3.3％（1／30），x^2=4．969，P〈0．05，有显著性意义；轻度、中度、重度CHB病人中HBVC基因型感染分别为6．3％（5／80）、15．0％（6／40）、75．0％（12／16），重度与轻度CHB比较，x^2=43．247，P〈0．05，有显著性意义；年龄≤30岁者B基因型HBV感染比例高，年龄〉30岁者C基因型比例高；基因型分布与性别无相关性。结论 HBV基因型的差别与地区分布、人群、致病性、和对治疗的反应有相关性。这有益于指导我们对乙型肝炎病人的临床诊疗工作。

Objective To discuss the relationship between the genotype distribution of Hepatitis B and clinic distribution. Methods To choose 390 serum HBV-DNA positive sufferers of our hospital from 2003 to 2005, in which there are 120 carriers of HBsAg, 180 chronic hepatitis B, 15 acute hepatitis B, 75 liver cirrhosis and to test the genotypes of the above subtypes of Hepatitis B, respectively. Results Between the course of disease≥5 yeas and 〈5 years, the HBVC genotype are 20.9%（10/46） and 3.3% （1/30）, x^2=4.969, P〈0.05. Distributing of the genotype infection of light, medium and severe CHB sufferer is 6.3% （5/80）, 15.0% （6/40） and 75.0% （ 12/16 ）, respectively, comparing the severe and the light CHB, x^2=43.247, P〈0.05. The B genotype HBV infection proportion is higher among the sufferers of the age ≤30, the C genotype inflection proportion is higher among the sufferers of age〉30. The genotype distributing has no relation with the sex. Conclusions The difference of genotype has relation with district distributing, people, nosogenesis and the reaction of treatment. This will instruct our clinic diagnosis and treat work to HBV sufferers.