替米沙坦和赖洛普利降压及对尿酸作用的比较

Comparement between telmisartan and lislnopril at effects on anti-hypertension and uric acid metabolism

目的比较替米沙坦和赖洛普利的降压疗效及对血尿酸的影响。方法采用随机、平行对照研究,一组35例高血压患者给予替米沙坦40mg,qd;另一组33例给予赖洛普利5mg,bid。12周后观察疗效及不良反应。结果替米沙坦组最高血压由(169.36±10.8)(/102.92±10.47)mmHg降为(145.48±14.78)(/81.45±9.57)mmHg,P<0.05;24h平均压由(149.73±8.93)(/93.21±10.68)mmHg降为(132.24±14.40)(/83.45±9.47)mmHg,P<0.05。赖洛普利组最高血压由(168.17±10.16)(/102.63±11.29)mmHg降为(146.9±14.83)(/85.25±7.14)mmHg,P<0.05;24h平均压由(148.90±9.16)/(92.54±11.23)mmHg降为(133.47±13.08)(/83.68±8.92)mmHg,P<0.05。替米沙坦组血尿酸由(446.56±110.56)"mol/L降为(378.52±78.95)"mol/L,P<0.05;赖洛普利组血尿酸治疗前、后为(445.23±112.14)"mol/L和(437.34±113.87)"mol/L,P>0.05。结论替米沙坦和赖洛普利降压疗效相似,但替米沙坦有降低尿酸的作用,建议高血压合并血尿酸增高患者选用替米沙坦。

Objective To compare between telmisartan and lislnopril at effects on anti-hypertension and uric acid metabolism. Methods 35 patients with telmisartan 40 mg per day, other 33 patients with lislnopril 5 mg bid, for 12 weeks. Results Highest blood pressure decreased from （ 169.36±10.8）/（ 102.90±10.47）mm Hg to （ 145.48±14.78）/（81.45±9.57）mm Hg, P〈0.05,24 h average blood declined from （149.73±8.93）/（93.21±10.68）mm Hg to （132.24±14.40）/（83.45±9.47）mm Hg in telmisartan group, P〈0.05 ; Highest blood pressure from （ 168.17±10.16）/（ 102.63±11.29 ）ram Hg to （ 146.9± 14.83 ）/ （85.25±7.14）mm Hg,P〈0.05, 24 h average blood pressure delined from （148.90±9.16）/（92.54±11.23）mm Hg to （133.47±13.08）/（83.68±8.92）mm Hg in lislnopril group,P〈0.05, anti-hypertension effects in 2 groups were not differencet signifi- cantly, P〉0.05. The concentration of serum uric acid decreased from （446.56±l10.56）μ mol/L to （378.52±78.95）μmol/L after treatment in telmisartan group, P〈0.05, The concentration of serum uric acid was （445.23±112.14）μmol/L and （437.34±l13.87）μmol/L before and afrer treatment in lislnopril group, P〉0.05. Conclusion Anti-hypertension effects were same in telmisartan and lislnopril, but telmisartan has the effect of decreasing hyperuricaemia. It is better for essential hypertension patient with hyperuricaemia using telmisartan to control blood pressure.