老年冠心病支架置入术前后血清IL-6,TNF-α水平改变的临床意义

Changes of serum levels of interleukin-6 and tumor necrosis factorα after coronary stent implanation in elderly patients

目的:观察冠状动脉内支架置入术后血清白细胞介素-6与肿瘤坏死因子-α水平的变化及临床意义。方法:选冠状动脉内支架置入术的患者30例,取支架置入前和术后24 h肘静脉血,做血清白细胞介素6,肿瘤坏死因子-α检测,并观察术后并发症及再狭窄的发生。与对照组30例(冠状动脉造影正常)进行对比。结果:冠心病患者血清白细胞介素6和肿瘤坏死因子-α较非冠心病患者明显升高(P<0.05);支架置入术后血清白细胞介素6和肿瘤坏死因子-α显著增高(P<0.05);发生再狭窄者较未发生再狭窄者术后血清白细胞介素6和肿瘤坏死因子-α显著增高(P<0.05)。结论:白细胞介素6和肿瘤坏死因子-α是反映支架置入术后早期炎性反应的敏感指标,可能在支架术后再狭窄发生过程中发挥作用。

Objective To investigate the changes of the serum level of interleukin-6 and tumor necrosis factor-α as well as their significance after coronary artery stent implantation in elderly patients. Methods Thirty patients underwent coronary artery stent implantation. Another 30 with normal angiogroph served as controls. Blood samples were taken from the vein 24 hours before and after successful coronary stenting. Serum concentration of interleukin-6 and tumor necrosis factor-α were measured and the complications as well as the occurrence of restenosis were observed after the procedure. Results The serum level of interleukin-6 and tumor necrosis factor-a were higher in the patients with coronary heart disease than the normal（P〈0. 05）. The concentration of interleukin-6 and turnout necrosis factor-α was significantly higher 24 hours after stent-implantion（P〈0.05） ;In patients with restenosis the concentration of interleukin-6 and trmour necrosis factor-α was significantly higher than the patients without restenosis. Conclusion Interleukin-6 and tumour necrosis factor-α are sensitive resembles of the early inflammatory response after coronary stent implanation. Interleukin-6 and turnout necrosis factor-α may play an important role in the incidence of complication and restenosis after stent implantation.