PTTG和b-FGF在前列腺癌中的表达与临床病理学特征的相关性研究

Correlation of pituitary tumor transforming gene and basic fibroblast growth factor expression in prostate cancer and its clinicopathological features

目的:探讨垂体肿瘤转化基因和碱性成纤维细胞生长因子在前列腺癌中的表达及其与临床病理学特征之间的关系,并探讨两者表达的相关性。方法:采用免疫组织化学链霉亲合素-生物素-过氧化物酶复合物法,检测51例前列腺癌和51例前列腺增生组织中垂体肿瘤转化基因和碱性成纤维细胞生长因子的表达情况。结果:垂体肿瘤转化基因和碱性成纤维细胞生长因子在前列腺癌和前列腺增生组织中的阳性表达率分别为72.55%和47.06%(P<0.01),58.82%和35.29%(P<0.05)。垂体肿瘤转化基因表达程度与前列腺癌的临床分期密切相关(P<0.05),而与其病理分级无关(P>0.05)。碱性成纤维细胞生长因子表达程度与前列腺癌的临床分期密切相关(P<0.05),与其病理分级无关(P>0.05)。垂体肿瘤转化基因和碱性成纤维细胞生长因子在前列腺癌中的表达程度呈正相关(P<0.01)。结论:垂体肿瘤转化基因、碱性成纤维细胞生长因子的高表达可能参与了前列腺癌的发生,在前列腺癌的侵袭和转移中发挥重要作用,且二者具有协同作用。

Objective To investigate the expression of pituitary tumor transforming gene and basic fibroblast growth factor in prostate cancer and their relationship with clinicopathological features, and the correlation between expression of pituitary tumor transforming gene and that of basic fibroblast growth factor in prostate cancer. Methods The expression of pituitary tumor transforming gene and basic fibroblast growth factor in 51 prostate cancer specimens and 51 benign prostatic hyperplasia specimens were detected by immunohlstochemical technique SABC method. Results The positive expression rates of pituitary tumor transforming gene and basic fibroblast growth factor in prostate cancer and benign prostatic hyperplasia tissues were 72.55% and 47.06%（P〈0. 01）, 58.82% and 35.29% （P〈0. 05）, respectively. The expression of pituitary tumor transforming gene was closely related to clinical stage of prostate cancer （P〈0.05）, but not related to subset of cells of prostate cancer （P〉0.05）. Expression of basic fibroblast growth factor was closely related to clinical stage of prostate cancer （P〈0.05）, but not related to subset of cells of prostate cancer （P〉0.05）. There was a positive correlation between the expressive intensity of pituitary tumor transforming gene and that of basic fibroblast growth factor （P 〈0. 01）. Conclusion Up-regulation of pituitary tumor transforming gene and basic fibroblast growth factor expression may be involved in the carcinogenesis of prostate cancer, and it may play an important role in invasion and metastasis of prostate cancer. Pituitary tumor transforming gene and basic fibroblast growth factor play a cooperative role in the process of prostate cancer.