骨显像和血清骨型碱性磷酸酶在鼻咽癌骨转移的应用

Diagnosis of osseous metastases of nasopharyngeal carcinoma by bone scanning combined with bone alkaline phosphatase detection

目的:探讨骨显像和血清骨型碱性磷酸酶对鼻咽癌早期骨转移的诊断价值。方法:对71例鼻咽癌患者进行骨显像并测定血清骨型碱性磷酸酶水平,比较骨转移组和无骨转移组的血清骨型碱性磷酸酶水平。结果:71例鼻咽癌患者中,骨转移者44例,无骨转移者27例,转移率62%;骨转移组血清骨型碱性磷酸酶水平与无骨转移组差异显著(P<0.01)。结论:鼻咽癌骨转移率较高,且血清骨型碱性磷酸酶与骨显像有一致性。

Objective To assess the diagnostic value of bone alkaline phosphalase detection and radionuclide bone imaging in the diagnosis of osseous metastases of nasopharyngeal carcinoma. Methods Bone scanning and bone alkaline phosphalase detection were performed in 71 patients with nasopharyngeal carcinoma. According to the findings in bone imaging and clinical symptoms, the patients were divided into bone metastases group （BM） and non-bone metastases group （NBM）,to compare the bone alkaline phosphalase by t test. Correlation analysis was performed between bone alkaline phosphalase level. Results Among the 71 patients,bone scanning showed osseous metastases in 44 patients. The incidence of bone metastases was 62%. Bone alkaline phosphalase was （24. 1 ± 18.9） u/L in BM group and （6.8±1.6） u/L in NBM group ,showing significant difference（t= 5.68,P〈0. 01 ）. Conclusion Bone alkaline phosphalase level detection and bone imaging yield consistent results. Bone scanning is the primary choice to diagnose osseous metastases in patients with nasopharyngeal carcinoma. If the patients can not be performed radionuclide bone imaging, bone alkaline phosphalase should be performed to help diagnosis.