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广东汉族人群HLA-Cw基因座的等位基因多态性分析 被引量：2

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摘要 目的调查广东汉族人群人类白细胞抗原（HLA）-Cw基因座的等位基因分布，并比较分析中国人群HLA-Cw基因的分布特征。方法采用结合聚合酶链式反应（PCR）-测序分型（sequence based typing，SBT）方法对160例广东汉族骨髓供者的HLA-Cw基因的第2，3外显子进行序列分析。结果广东汉族群体中共检出20种HLA-Cw等位基因，频率分布为0．0031～0．2094，其中Cw＊070201（0．2063）、Cw＊0102（0．1937）、Cw＊0304（0．1563）、Cw＊0302（0．0906）和Cw＊080101（0．0781）比较常见。70检验表明其基因型分布符合Hardy-Weinberg平衡定律。结论建立广东汉族人群HLA-Cw基因座的等位基因频率数据库，为法医学、人类学、医学研究和应用提供重要的群体遗传学资料；同时发现HLA-Cw等位基因在中国人群中呈现规律性分布。
作者 李文青 朱为刚 白英伟 鲍自谦 蓝欲晓 金士正 邹红岩 高素青 程良红
机构地区 暨南大学附属第二医院 广东省深圳市血液中心 大连医科大学医学检验系
出处 《广东医学》 CAS CSCD 北大核心 2006年第8期1136-1138,共3页 Guangdong Medical Journal
基金 广东省科技计划项目(编号:2005B36001079)
关键词 人类白细胞抗原(HLA)-Cw 等位基因 多态性
分类号 R392 [医药卫生—免疫学] R446 [医药卫生—诊断学]
  • 相关文献

参考文献13

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共引文献40

同被引文献44

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二级引证文献12

广东医学
2006年 第8期

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