马来酸曲美布汀治疗功能性消化不良疗效观察

The efficacy and safety of trimebutine maleate in the treatment of functional dyspepsia

目的观察马来酸曲美布汀治疗功能性消化不良(FD)的临床疗效。方法选择FD患者64例,随机分为对照组和治疗组各32例。治疗组给予马来酸曲美布汀200mg口服,1日3次;对照组给予谷维素10mg口服,1日3次,疗程2周。观察治疗前后症状变化。结果马来酸曲美汀对嗳气有效率为84·6%、恶心有效率为86·7%、腹胀有效率为81·2%、腹痛治疗有效率为90·4%、腹泻有效率为84·6%、便秘有效率为85·7%,总体评估总改善率为82%。无明显不良反应。结论马来酸曲美汀治疗FD是安全有效的。

Objective To validate the clinical safety and efficacy of trimebutine maleate in the treatment of functional dyspepsia（FD）. Methods 64 patients with FD were recruited into the study and ramdomly divided into two groups,each 32 examples. The observed group was given trimebutine maleate 200mg, po, tid, and the matched group was given oryzanol 10mg po,tid. The treatment circumstance was recorded one day before the treatment,and once a week for two weeks. Results After 2 weeks observation, drug efficacy to the symptom of naupathia, abdominal pain, diarrhoea and constipation were 86.7 %, 90.4 % ,84.6 % and 85.7 %, respectively. The observed group had gross efficiency for 82 96, with the machted group for 54.0 %. No side effect was observed. Conclusion Trimebutine is an effective agent for treatment of FD,and has no obvious side effect.