动脉内灌注化疗及栓塞治疗骨与软组织恶性肿瘤的临床与病理观察

The clinical and pathological observation for the intervention therapy of bone and softtisue malignant tumors

目的通过临床及术后病理观察,探讨介入放射学对骨与软组织恶性肿瘤的治疗价值。方法对36例经病理证实的骨与软组织恶性肿瘤患者行选择性血管造影、动脉内灌注化学药物治疗和栓塞治疗;观察治疗后临床、病理改变。结果治疗后临床指标94·4%(34/36)得到改善;肢体肿瘤患者保肢手术达到72·2%(26/36);手术病理显示总的组织有效率达80%(16/20);60%(12/20)的患者肿瘤坏死率达90%以上。结论介入治疗是骨与软组织恶性肿瘤治疗的有效方法,能提高保肢手术的效果。

Objective To investigate the value of interventional radiological treatment of bone and softtissue malignant tumor. Methods 36 patients with bone and softtissue malignant tumors, who were diagnosed by pathology, admitted selective angiography,intra-artery chemotherapy and embolize. After treatment the clinical and pathological changes were observed, and the treatment effect were analyzed. Results After treatment the clinical signs of most of patients（94.4 % ,34/36） were ameliorated. The pathological examination indicated that the total rate of curative effect achieved 80 % （16/20） ;The tumor putrescence rate of 60 % patients was exceeded 90 %. Conclusion Intervention therapy is an effective method for bone and softtissue malignant tumors, and it can improve the result of limb salvage operation.