^(125)I粒子组织间植入治疗2例恶性肿瘤放化疗失败病例临床分析

Clinical analysis of ^(125)I seed implants in worst-casts of the malignant tumors after radiography and chemotherapy.

目的探讨125I粒子组织间植入治疗恶性肿瘤放化疗失败病例的疗效及副反应。方法回顾性分析放化疗失败的恶性肿瘤患者,经皮穿刺或术中直视下将125I粒子永久性植入瘤床,随访血常规、症状、体征,B超或CT观察肿瘤变化情况及粒子分布情况等。结果共治疗2例3人次,肿块明显缩小,症状明显改善,溃疡面愈合,未见粒子移位,血象未见明显下降。结论125I粒子组织间永久性植入为放化疗失败病例提供了一种新的治疗方法,近期疗效确切,毒副反应小,可弥补放化疗治疗的不足。

Objective To investigate the curative effect and side reaction after ^125I seed implanted among tissue were treated the malignant neoplasm by radiography and chemotherapy. Methods Retrospective analysis the cancerous sufferer after the failure of radiography and chemotherapy, percutaneous puncture or intraoperative under gaze forward ^125I seed were implanted the bed of the tumour forever. Follow-up blood routine examination, symptom, sign, using USG or CT observe the change of the tumour and the distribution of the particles etc. Results In 3 cases, neat 2 cases, tumour reduced obviously, symptoms improved obviously, the face of the ulcer cured, the particles didn＇t shift, hemogram didn＇t decline obviously. Conclusion ^125I seed among the tissue implanted forever for the unsuccessful case after radiography and chemotherapy supply a new therapeutic methods. In the neat future curative effect is exactly, toxic reaction is small, which can remedy the deficiency of the treatment for radiography and chemotherapy.