摘要
应用高效液相色谱法(HPLC)比较了普通粉碎和超微粉碎对黄连解毒散中主要有效成分栀子苷和小檗碱溶出量的影响.结果表明,超微粉碎未改变黄连解毒散固有的药效学成分,可增加栀子苷和小檗碱的溶出量,在超声提取下超微细粉中栀子苷和小檗碱含量分别比细粉提高26.26%和37.07%.
The high-performance liquid chromatography （HPLC） method was developed to determine the effects of ultramicro-pulverization on the geniposide and berberine dissolubility of Huanglianjiedusan （HLJDS）. The results showed that the ultromiero-pulverization method eould not only keep natural ingredients of HLJDS, but also improved the dissolubility of geniposide and berberine, meanwhile eompared to the eonventional fine powder, their eontent inereased by 26.26% and 37.07% respeetively with the method of ultrasonie wave extraetion.
出处
《福建农林大学学报（自然科学版）》
CSCD
北大核心
2006年第4期394-397,共4页
Journal of Fujian Agriculture and Forestry University:Natural Science Edition
基金
福建省科技厅重点资助项目(2004N031)
关键词
黄连解毒散
超微粉碎
高效液相色谱法(HPLC)
栀子苷
小檗碱
Huanglianjiedusan （HLJDS）
ultramicro-pulverization
high-performance liquid chromatography （HPLC）
geniposide
berberine
