糖链变化对肿瘤转移的影响及在肿瘤疫苗中的应用

Glycan changes:cancer metastasis and anti-cancer vaccines

在许多恶性肿瘤中存在多种糖链结构的改变,这些变化在细胞整体水平与分子水平影响肿瘤的转移能力。现着重介绍近几年关于几种糖链变化对肿瘤转移能力影响的研究新发现,以及在此基础上发展的肿瘤疫苗治疗方法的研究进展。

Changes in glycosylation are often hallmark in malignant tumors. Those changes happened on the whole cells or some specific molecules. The review focuses on the recent recognitions in the correlationship between glycosylation and the metastasis potential of tumor cells. Utilizing these glycosylations in development of anti-adhesion approach to prevent tumor metastasis, development of anti-cancer vaccine is one of promising targets of future study.