脱水长春碱合成新工艺

A novel synthetic technique of anhydrovinblastine

目的:合成抗肿瘤新药脱水长春碱。方法:以长春质碱和文多灵为原料经2步反应合成脱水长春碱。结果:脱水长春碱结晶物收率为34．29%,目标产物经紫外光谱、红外光谱、质谱、核磁共振氢谱得到确证。结论:新的合成方法工艺简单,操作安全,适合生产。

Objective： To synthesize an anti-tumor agent anhydrovinblastine. Methods： The target compound was synthesized via two steps from catharanthine and vindoline as starting materials. Results： A total yield of 34.29% was obtained and the chemical structure of the target compound was confirmed by UV, IR, MS and ^1H-NMR. Conclusion： The easily manipulated new synthetic procedure is worthy to have further pilot manufacture.