高渗盐水治疗低血容量性休克

Hypertonic solutions in treatment of hypovolemic shock

通过前瞻性双盲法研究，比较应用７．５％ＮａＣｌ（高渗盐水组）与等渗盐水（０．９％ＮａＣｌ）对１８０例低血容量性休克患者的治疗效果。结果：高渗盐水组疗效明显优于等渗盐水组：升压效果显著，能快速扩容，患者尿量充分，抢救过程中补液总需量和血量需要较少，无相关并发症，病死率有所降低。

This prospective doubleblind study compared the effects of a bolus infusion of 7 5% NaCl and isotonic saline in the treatment of 180 patients with hypovolemic shock.The result showed that the therapeutic effectiveness of hypertonic saline was significantly better than that of isotonic saline.Bolus infusion of 300ml hypertonic saline in the treatment of patients with hypovolemia was effective in immediately restoring MAP to normal levels,rapidly expanding the plasma volume by 25 7%±1 1%,increasing urine output,significantly reducing the volume of crystalloids and blood required in the resuscitation.No related complications were seen.The mortality rate was reduced.It is considered that the use of hypertonic saline is more appropriate in the emergent treatment of hypovolemic shock.