血清丙二醛和超氧化物歧化酶水平与病情转归的关系

Relationship of levels of malonyl dialdehyde and total superoxide dismutase with the outcome of illness

为探讨丙二醛（ＭＤＡ）、总超氧化物歧化酶（ＴＳＯＤ）与病情转归的关系，动态观察了２９０例常见病患者病情发展不同阶段ＭＤＡ、ＴＳＯＤ变化规律。结果：病情越重ＭＤＡ含量越高，ＭＤＡ≥８．８μｍｏｌ／Ｌ者预后不良，ＭＤＡ逐渐升高示病情恶化；疾病早期ＴＳＯＤ活性正常或升高，疾病晚期ＴＳＯＤ活性降低，ＴＳＯＤ与ＭＤＡ呈负相关（ｒ＝０．９５）；治疗后ＭＤＡ含量下降、ＴＳＯＤ活性升高者均能康复，治疗后ＭＤＡ含量升高、ＴＳＯＤ活性下降者均死亡。

n order to study the relationship of malonyl dialdehyde(MDA) and toal superoxide dismutase ( TSOD )with the outcome of illness,the dynamic changes of MDA and TSOD in the different phases of illness were observed in 290 patients with commonly seen diseases.The result showed that the severer the disease,the higher the content of MDA.The prognoses of the patients whose MDA was 8 8μmol/L were poor.The patient's condition deteriorated when MDA was increasing.In the early stage of the disease,TSOD activity was normal or increased,while in the late stage,it was decreased;there was a negative correlation between TSOD and MDA( r =0 95).The patients in whom MDA content was decreased and TSOD activity was increased after treatment all recovered,whereas in whom MDA increased and TSOD decreased all died.It is suggested that the dynamic observation of MDA and TSOD is of certain value for judging the patient's condition and predicting the prognosis.