阵发性运动障碍25例临床分析

Clinical Analysis in 25 Patients with Paroxysmal Dyskinesia

目的总结阵发性运动障碍患者的诱发因素、临床特征以及治疗特点。方法收集阵发性运动障碍患者25例,均进行神经科常规检查以及视频脑电和核磁共振扫描,部分患者进行单光子发射计算机断层扫描,并对其诱发因素、发病年龄以及临床表现进行分析,观察对抗癫药物治疗的效果。结果25例患者中,散发14例,有家族史患者8例,继发性3例。其中阵发性运动源性舞蹈样徐动症/运动障碍共19例,对小剂量卡马西平治疗有显著效果。结论不同类型的阵发性运动障碍诱发因素不同,对卡马西平的治疗效果也不同;继发性阵发性运动障碍要重视原发病治疗。

Objective： to summarize clinical and therapeutic features of paroxysmal dyskinesia. Methods： 25 patients with paroxysmal dyskinesia all underwent neurological routine examinations, visual electroencephalograph, magnetic resonance imagine and partly with single photo emission computed tomography. To sum up and analyse their induce factors, ages, clinical manifestations and effect treated by carhamazepine. Results： Sporadic , secondary and family history positive cases were respectively fourteen, three and eight. Nineteen case were diagnosed as paroxysmal kinesigenic choreoathetosis /dyskinesia and had marked effect to low dose carbamazepine. Conclusions： Different types of paroxysmal dyskinesia had different induce factors and effect treated by carhamazepine was also different. Special attention should he given on treatments on the primary affections in those secondary cases.