脑源性神经营养因子基因多态性与散发性帕金森病的相关性研究

Association Study of Brain-Derived Neurotrophic Factor Genetic Polymorphisms and Sporadic Parkinson Disease

目的探讨脑源性神经营养因子(Brain-DerivedNeurotrophicFactor,BDNF)基因多态性与散发性帕金森病(SporadicParkinson'sDisease,SPD)的相关性。方法采用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)分析方法对196例健康人和85例SPD患者进行基因分型;利用x2检验统计分析实验数据。结果两组间BDNF基因G196A和C270T多态性位点各基因型和等位基因频率差异均无显著性(P>0.05)。结论BDNF基因多态性与SPD无显著相关性。

Objective： To investigate the relationship between brain-derived neurotrophic factor（BDNF） genetic polymorphisms （G196A and C270T） and sporadic Parkinson＇s disease（SPD）. Methods：The genotype of 196 healthy controls and 85 SPD patients was analyzed with the polymerase chain reaction-restriction fragment length polymorphism technique; X^2 test was used to estimate p values. Results ： G/A genotype was dominant in both groups and no T allele was found. There were no significant differences in genotype and allele frequencies of G196A and C270T between SPD and control group. Conclusions： No association existed between BDNF genetic polymorphisms and SPD in Han population of Huazhong area.