特发性血小板减少性紫癜骨髓巨核细胞数与预后关系

Prognostic significance of bone marrow megakaryocyte in patients with Idiopathic thrombocytopenic purpura

目的探讨特发性血小板减少性紫癜(ITP)患者骨髓巨核细胞数与预后的关系。方法回顾性分析124例ITP患者的预后与初诊时骨髓涂片巨核细胞的数量、原始幼稚巨核细胞百分数的关系。结果初诊时骨髓巨核细胞计数越多,预后越好;初诊时骨髓原始幼稚巨核细胞比例越高,预后越好。结论初治时骨髓巨核细胞的数量、原始幼稚巨核细胞百分数与ITP预后有密切关系,可作为早期判断ITP预后的指标。

[Objective] To investigate the prognostic significance of bone marrow megakaryocyte in patients with Idiopathic thrombocytopenic purpura. [Method] A series of data of 124 ITP patients including the counts of the megakaryocyte and the percentage of megakaryoblast and promegakaryocyte on the bone marrow smears at diognosis were collected and retrospectively analyzed to correlate with the disease development. [Result] The numerous megakaryocyte counts and the high proportion of megakaryoblast and promegakaryocyte at diognosis indicated good prognosis. [Conclusion] The counts of the megakaryocyte and the percentage of megakaryoblast and promegakaryocyte at diognosis have intimate relationship with the prognosis of ITP patients, it can be an early index to predict prognosis of ITP patients.