缺血性脑血管病患者血浆LCAT活性的初步探讨

Determination of LCAT activity in plasma of patients with ischemic cerebrovascular disorders.

本文应用外加底物法测定１０３例缺血性脑血管病（ＩＣＶＤ）病人和３６例健康人的血浆ＬＣＡＴ活性和脂蛋白含量，病人组包括脑动脉硬化症患者４０例，脑血栓形成患者６３例。研究结果表明：ＩＣＶＤ患者血浆ＬＣＡＴ活性下降，脑血栓形成急性期下降尤著（Ｐ＜０．００１）；ＬＣＡＴ活性与ＨＤＬ－Ｃ、ＨＤＬ２－Ｃ及ａｐｏＡ－Ｉ呈正相关，与ＬＤＬ－Ｃ／ＨＤＬ－Ｃ呈负相关，其中与ＨＤＬ－Ｃ相关性最强（Ｐ＜０．０２）。

The LACT activity and lipoprotein compositions were determined in plasma of 103 patients with ischemic cerebrovascular disorders(ICVD) and 36 healthy subjects.LCAT activity was determined by a method involving the use of exogenous substrate.Two groups of patients were included:40 patients with cerebral atherosclerosis,63 with cerebral thrombosis.The results revealed a lower LCAT activity in patient group,particularly in the acute stage of cerebral thrombosis.LCAT activity correlated positively with HDL C,HDL 2 C,apoA I and negatively with LDL C/HDL C.The highest correlation coefficient was found between LCAT activity and HDL C( P <0.02).These findings indicate that a decreased LCAT activity could be considered as a risk biochemical factor for atherosclerotic ICVD.