儿童癫痫及抗癫痫治疗对血脂水平影响的研究

The research on the Blood lipid level effect by epitepsy and antiepileptic therapy in children.

对１１４例儿童癫痫患者的血脂水平进行监测。结果发现癫痫本身对血脂水平无影响，抗癫痫药物治疗后总胆固醇（ＴＣ）和甘油三脂（ＴＧ）明显增高（Ｐ＜０．００１），且随治疗时间的延长差异更为明显（Ｐ＜０．００１），高密度脂蛋白（ＨＤＬ）无变化。丙戍酸钠（ＶＰＡ）对血脂无影响，而苯妥英钠（ＰＨＴ）、苯巴比妥（ＰＢ）、卡马西平（ＣＢＺ）可使ＴＣ、ＴＧ明显升高。提示在治疗儿童癫痫期间要常规监测血脂水平。

The levels of blood lipid in 114 epileptic children were examined.The results showed that epilepsy itself did not influence the levels of blood lipid,but the total cholesterol (TC) and triglycerid (TG) were significantly increased after antieptleptic therapy ( P <0.001) High density lipoprotein (HDL) did not changed.Although sodium valproate (VPA) did not influence the level of blood lipid,sodium (PHT) phenytoin phenobarbitalum (PB) and carbamazepin (CBZ) could increased TC and TG significantly.The results suggest that the routine surveillance of blood lipid in epileptic children should be done during the antiepileptic therapy,and the suitable alimentary therapy is the key to prevent the adult arteriosclerosis.