重症肌无力患者单纤维肌电图测定及临床意义

The study on Jitter with single fiber EMG in MG.

对４５例重症肌无力（ＭＧ）患者进行单纤维肌电图（ＳＦＥＭＧ）测定，其中Ⅰ型１８例，ⅡＡ型和ⅡＢ型２７例，结果Ｊｉｔｔｅｒ（ＭＣＤ）均值：Ⅱ型（８６．７０８±３４．７２８μｓｅｃ）明显延长于Ⅰ型（３０．８８９±７．４０８μｓｅｃ）；Ⅱ型阳性率８８．９％（２４／２７），Ⅰ型阳性率３８．９％（７／１８）；Ⅱ型Ｊｉｔｅｒ阻滞率４４．４％，Ⅰ型未见阻滞电位。结合文献复习，认为ＳＦＥＭＧ是目前诊断ＭＧ最敏感的电生理检查方法，ＳＦＥＭＧ可帮助判断病情。

Single Fiber electromyography (SFEMG) study was carried out in 45 cases with a wellestablished diagnosis of MG.The abnormal SFEMG on E.D.C were observed in 31 cases with MG 68.9%(31/45),in which grade Ⅱ MG was 88.9%(24/27)and grade Ⅰ MG was 38.9%(7/18).44.4% Jitter block of SFEMG was observed in grade Ⅱ MG,and there was no Jitter block of SFEMG in grade Ⅰ MG.The mean values of MCD(mean concetive difference) were 86.708±34.728 in grade Ⅱ MG and 30.889+7.408 in grade Ⅰ MG ( P <0.05). SFEMG can provided a sensitive index in diagnosising defective of neuromusclar transmission in MG.