sIL-2R与TNF-α在银屑病发病机制中作用的研究

Study on the Role of sIL 2R and TNF α in the Pathogenesis of Psoriasis

本研究对４３例寻常型银屑病患者，应用ＥＬＩＳＡ方法测定血清中ｓＩＬ２Ｒ及ＴＮＦα含量，并设２３例正常人作对照。结果表明，银屑病患者血清中ｓＩＬ２Ｒ与ＴＮＦα水平与正常对照组相比明显升高，增高程度分别与银屑病面积及严重程度指数积分相关，进展期ｓＩＬ２Ｒ水平较静止期增高，而疗后较疗前下降。除此以外，ｓＩＬ２Ｒ与ＴＮＦα相关。因此，说明ｓＩＬ２Ｒ与ＴＮＦα分别与银屑病的炎症产生和持续存在有关。本实验为探讨银屑病免疫学发病机制提供了进一步的理论依据。

Serum levels of soluble interleukin 2 receptors (sIL 2R) and tumor necrosis factor α (TNF α) in 43 patients with psoriasis vulgaris were examined with ELISA,together with 23 healthy controls.The results indicated that the mean serum levels of sIL 2R and TNF α in psoriatic patients were remarkedly higher than those in controls and were related to psoriasis area and severity index (PASI) score.sIL 2R level in the stadium augmenti was higher than that in the resting stage,and level of sIL 2R after treatment was lower than before.In addition,a positive correlation was noted between the sIL 2R level and TNF α level.These results showed that sIL 2R and TNF α may be relevant to the induction and perpetuation,respectively,of the inflammatory responeses in psoriasis.The experiment provided the theoretical basis to seek the immunologic pathogenesis of psoriasis.