异丙酚和芬太尼在胃镜检查中的应用

Study on painless gastroscopy with propofol and fentanyl

目的探讨联合应用异丙酚和芬太尼在胃镜检查中的镇静效果和安全性。方法胃镜检查患者1476例给予异丙酚和芬太尼,633例不予任何镇静剂,比较2组胃镜检查中患者的反应和感受、检查时间,观察检查前、中、后血压、心率、和血氧饱和度的变化。结果镇静组患者99.25%无不适感,而对照组29.1%无明显不适感(P<0.01)。镇静组患者咳嗽、躁动、恶心呕吐和咽喉不适的发生率明显低于对照组(P<0.01),镇静组胃镜检查时间短于对照组(P<0.01),镇静组术后清醒时间1.6±1.5min,检查中血压有所下降,但检查结束后很快恢复到检查前水平。结论胃镜检查时适量应用异丙酚和芬太尼镇静麻醉是一种安全、有效的方法。

Objective To stuay the efficacy and safety of sedation for gastroscopy with a combined use of propofol and fentongl compared to acontroL, non-sedative group, with the goal of establishing a method of painless gastrusaony ,Methods Ohe thousand four hundred seventy six patients in sedative group were given intra venousr urepeoinl and tentanyl .Patients＇s feeling and discomfort,operator＇s satisfaction and operative duration venous were companut ,opth the Control group（n=633, without sedation）. The changes of blood pressure,heart rate and blood oxygen saturation were recorded and analysed. Results One thousand four hundred sixty five patients （99.25%）in sedative group and 184 petients（29.1%）in control group did not complain any discomfort and pain during gastroscopy（P〈0.01 ）, The operative duration of sedative group was shorter than of control group. The recover/ time of sedative group was（1.6±1.5）minutes. The blood pressure in sedative group was decreased during the procedure and recovered after the procedure, Conclusions With intravenous use of pmpofol and fentanyl, gastroscopy can be performed effectively and safely.