一起柯萨奇B5病毒感染引起疾病暴发的流行病学调查

The Report of Epidemiological Investigation on the Outbreak of Coxsackievirus B5 Viral Infection

目的了解当地肠道病毒感染的现状,为做好该地区肠道病毒感染的防治工作提供科学依据。方法运用现场流行病学调查方法,对所有发热病例进行流行病学调查,同时结合实验室检测结果进行进一步诊断。结果2005年5月19日—6月21日,信阳市狮河区狮河港乡西湾村发现一批以发热、头痛和头晕为主要临床表现的儿童。患者分布在该行政村的14个自然村,主要集中在1～12岁年龄段。经河南省疾病预防控制中心实验室用肠道病毒通用引物套式PCR检测及大便病毒培养鉴定,证实为柯萨奇B5病毒感染。结论本次为河南省首起柯萨奇B5病毒感染引起的病毒性脑炎。

OBJECTIVE Characterizing and analyzing the epidemiological and clinical features of the unidentified fever cases occurred in June, 2005 in Xinyang, Henan Province and finding its causes. METHODS Using methods of field epidemiological investigation as well as serological, immunological and molecular-biological diagnosis to identify the etiological factor of this outbreak. RESULTS In the year of 2005, there was an outbreak of unidentified febrile disease in Xiwan village of Shihewan Town of Shihe County that is located in the southern part of Henan Province. Since 19^th May to 21^nl Jun 49 cases were reported. All patients were under 12 years. The main clinical symptoms were fever, Some cases had headache, dizziness. Virogene of enteroviruses were amplificated by PCR from 2 era, 2 fecal and 2 CSF specimens, CoxsackievirusB5 was isolated from 8 fecal specimens. CONCLUSION The first outbreak of Viral encephalitis caused by Coxsackievirus B5 was discovered in Henan province.