β－胡萝卜素对扑热息痛致小鼠肝损害预防作用的初步研究

Preliminary study on the protection by β-carotene against acetaminophen hepatotoxicity in mice

本文报告了用β－胡萝卜素预防扑热息痛所致肝脏损害的效应。大剂量扑热息痛２００ｍｇ／ｋｇ腹腔注射引起小鼠血浆ＡＬＴ活性和肝脏脂质过氧化产物丙二醛（ＭＤＡ）含量显著增高，还原型谷胱甘肽（ＧＳＨ）耗竭，肝细胞出现病理改变。用β－胡萝卜素进行预处理则能明显改善上述各项指标，ＡＬＴ和ＭＤＡ下降，ＧＳＨ回升，肝细胞病理改变减轻。

This paper first reports the protective action of β-carotene against acetaminophen (AP)-induced hepatotoxicity in mice, AP 200mg/kg(ip) enhanced the activity of serum ALT, increased the contentof liver MDA,and induced depletion of liver GSH and injury the hepatocyte structure.Pretreatment with β-carotene could alleviate changes of above-inentioned indexes in AP-treated mice.