云南狗牙花总碱的镇痛作用

Antinociceptive effects of total Ervatamia yunnansis alkaloid in mice

目的:研究云南狗牙花总碱(total Ervatamia yuunansis alkaloid,TEYA)对小鼠的镇痛作用。方法:采用小鼠热板法,观察TEYA的镇痛作用及对吗啡的镇痛作用的影响。结果:与同期对照组相比,TEYA的3个剂量组均可显著提高小鼠的病阈值,镇痛效果随剂量的增加呈剂量依赖关系;同时给予TEYA(10、20mg／kg)和吗啡4mg／kg,有协同镇痛的作用;纳洛酮4mg／kg可以部分拮抗TEYA的镇痛作用。结论:TEYA有明显的镇痛作用,其作用可能部分通过阿片受体来实现。

Objective： To observe the antinociceptive effect of total Ervatamia yunnansis alkaloid（TEYA） in mice. Methods： The mice hot-plate antinociceptve test was used to study the analgesic effects of TEYA and the effect on morphine in mice. Results： The three groups with different dosage of TEYA could significantly increase the pain threshold in mice and the effects increased in a dose-related manner. TEYA（ 10,20 mg/kg） combined with morphine 4 mg/kg had a synergic analgesic eftect. The analgesic effect of TEYA could be partly blocked by naloxone 4 mg/kg. There were significantly differences between administration group and control group in the hot-plate test. Conclusion： TEYA has significant antinocieeptive activity in hot-plate test in mice which may be mediated by way of opioid receptors.