发育期慢性阿托品化眼猫背侧外膝体的细胞形态学改变

CYTOMORPHOLOGICCHANGESOFDORSALLATERALGENICULATENU┐CLEIOFTHECATSWITHCHRONICALLYATROPINIZEDEYEINVISUALDE┐VELOPMENTALPERIOD

目的：探讨屈光参差性弱视和屈光不正性弱视的发病机理。方法：用幼猫视觉发育期单眼和双眼慢性阿托品化的方法塑造上述两种动物模型，成年后摘除外膝体，进行ＧｏｌｇｉＣｏｘ染色，观察计算背侧外膝体（ｄｏｒｓａｌｌａｔｅｒａｌｇｅｎｉｃｕｌａｔｅｎｕｃｌｅｕｓ，ｄＬＧＮ）Ａ１层的胞体截面积的树突野的有关参数。结果：实验动物ｄＬＧＮＡ１层的ｃｌａｓｓ１和ｃｌａｓｓ２细胞胞体的截面积和树突野各参数的改变均为：单眼阿托品化眼所支配的细胞与正常眼的差异均有显著性，双眼阿托品化眼与正常眼差异有显著性，单眼阿托品化眼与双眼阿托品化眼之间差异无显著性。结论：屈光参差性弱视与屈光不正性弱视可能具有相似的发病机制。

PURPOSE:Toexplorethepathogenesisofanisometropicandametropicamblyopias.METHODS:Tocarryoutonmonocularandbinocularatropinizedcatmodelsduringthedevelopmen-talperiodforanisometropiaandametropia,andmeasurethecytosomalsectionalareaandsomepa-rametersofthedendricfieldfromthedorsallateralgeniculatenuclei(dLGN)ofadultcatsbyusingGolgi-Coxstaining.RESULTS:Thechangesofcytosomalsectionalareasandparametersaboutden-dricfieldsinthedLGNofexperimentalcatswereasfolowing:significantdiferencesbetweencelsofdLGNsA1laminabythemonocularatropinizedeyesandnormalones,binocularatropinizedeyesandnormalones;nosignificantdifferencebetweenthatdrivenbythemonocularandbinocularat-ropinizedeyes.CONCLUSIONS:Theremightberesemblepathogenesisbetweenanisometropicandametropicamblyopias.