中药干预糖耐量低减的可行性及其优势

Feasibility and advantage of traditional Chinese medicine in the intervention of impaired glucose tolerance

目的:探讨中药对糖耐量低减干预的可行性,并对其优势进行总结。资料来源:应用计算机检索PUBMED1966-01/2006-01的相关文章,检索词为“impairedglucosetolerance,treatment,intervention”,并限定文章语言种类为English。同时计算机检索万方数据库2000-01/2006-01的相关文章,检索词为“糖耐量低减,干预,中医药”,并限定文章语言种类为中文。资料选择:对资料进行初审,并查看每篇文献后的引文。纳入标准:文章所述内容应与中药对糖耐量低减干预的可行性及其优势的研究相关。排除标准:重复研究或Meta分析类文章。资料提炼:共收集到391篇相关文献,30篇文献符合纳入标准,排除的361篇文献为内容陈旧或重复。符合纳入标准的30篇文献中,6篇涉及预防糖尿病的著名临床研究,1篇涉及目前干预措施的不足,14篇涉及中医药对IGT的干预的可行性和优势,10篇涉及存在的问题与展望。资料综合:糖尿病是一种严重危害人类健康的慢性疾病,尤其是2型糖尿病所带来的经济负担已对全球产生了巨大影响。鉴于目前尚无有效的根治措施,其早期预防便成了全球关注的焦点。世界范围内进行了多项大型预防糖尿病的临床试验,主要分为生活方式干预和药物干预两大类。这些研究为糖尿病的预防提供宝贵经验的同时也暴露了一些不足,为更好地开展糖尿病的预防工作,探讨切实可行、依从性好、毒副作用小、更符合药物经济学要求的预防方法尤为关键。中医药毒副作用小、价格相对低廉、患者依从性好,具有改善胰岛素抵抗、保护胰岛β细胞、全面控制心血管危险因素以及抗衰老等作用。结论:中医药对糖耐量低减干预存在一定可行性和潜在优势。

OBJECTIVE： To explore the feasibility of traditional Chinese medicine in the intervention of impaired glucose tolerance and summarize its advantage. DATA SOURCES： Related articles were searched in PUBMED published from January 1966 to January 2006 with the keywords of ＂impaired glucose tolerance,treatment,intervention＂ in English. Simultaneously, related articles were also searched in Wanfang Database published from January 2000 to January 2006 with the key words of ＂impaired glucose tolerance, intervention, traditional Chinese medicine＂ in Chinese. STUDY SELECTION： The data were selected primarily, and citation in the back of every article was searched. Inclusive criterion was those articles of the feasibility of traditional Chinese medicine in the intervention of impaired glucose tolerance and its advantage. Exclusive criteria were articles with repetitive research or Meta analysis. DATA EXTRACTION： Totally 391 related articles were collected, and 30 were accorded with the inclusive criterion. The excluded 361 articles were with old content or repetitive research. Of the included 30 articles, 6 were related to outstanding clinical research in the prevention of diabetes mellitus, 1 on the disadvantage of interventional measure at present, 14 about the feasibility and advantage of traditional Chinese medicine on IGT＇s intervention and 10 on existing problems and prospect. DATA SYNTHESIS： Diabetes mellitus was a. chronic disease that was severely harmful to human health, especially the economic loading due to type 2 diabetes mellitus had have great effect on global. Respecting there was no effective radical cure measure at present; its early prevention became a focus in the global. Multiple large clinical trials of preventing diabetes mellitus in the world were performed, which mainly assigned into life style intervention and drug intervention. These studies had provided some valuable experiences for preventing diabetes mellitus, but also exposed some disadvantages. For better developing the prevention of diabetes mellitus, feasible preventing methods with good compliance, little side effects, accorded with pharmacoeeonomics were the key. Traditional Chinese medicine was with little side effects, tow price, good compliance and had the effect of improving insulin resistance, protecting beta cells of islet, controlling fully cardiovascular risk factors and resisting aging, etc. CONCLUSION： The traditional Chinese medicine has certain feasibility and potential advantage in the intervention of impaired glucose tolerance.