6－甲氧基正丁苯酞在大鼠肝微粒体中的代谢研究

STUDIES ON METABOLISM OF 6 METHOXY BUTYL PHTHALIDE BY RAT LIVER MICROSOMES

报道了用ＧＣ／ＭＳ方法及衍生化技术研究６甲氧基正丁苯酞（ＭＢＰ）在大鼠肝微粒体中的代谢转化结果。６甲氧基正丁苯酞在苯巴比妥（ＰＢ）诱导的大鼠肝微粒体中主要转化为３羟基、γ羟基取代物。

The in vitro biotransformation of 6 methoxy butyl phthalide (MBP) by phenobarbital induced rat liver microsomes was investigated by GC/MS and GC/MS with TMS derivatization. Three major metabolites of MBP were identified as 3 OH MBP, 6 OH butyl phthalide and γ OH MBP. A less polar metabolite was tentatively identified as an epoxidation product.