摘要
观察不同浓度的磷酸肌酸(CP)对正常豚鼠心室乳头肌跨膜电位的影响。结果表明,CP10-9mol/L~10-4mol/L对RP、APA、OS和Vmax无明显影响,但可使APD明显变窄。从10-8mol/L开始,浓度越大,对APD50影响也越大,到10-3mol/L时细胞死亡。此结果提示,CP可能是一种钙拮抗剂,而且浓度10-7mol/L~10-5mol/L时效果最佳。
The effect of phosphocreatine (10 -9 mol/L~10 -4 mol/L) on action potentials of papillary myocardium in guinea pig was studied.The results showed that RP,APA,OS and Vmax not influenced,but APD was shortened apparently by CP.The effect appeared dose dependancy and showed stronger action from 10 -7 mol/L to 10 -5 mol/L.The results implied that CP is maybe a calcium antagonist.
出处
《哈尔滨医科大学学报》
CAS
1996年第4期329-331,共3页
Journal of Harbin Medical University