异波帕明滴眼对玻璃体视网膜手术、葡萄膜炎和眼部穿通伤引起的慢性低眼压的疗效研究

Topical ibopamine in the treatment of chronic ocular hypotony attributable to vitreoretinal surgery,uveitis,or penetrating trauma

PURPOSE: To study whether topical ibopamine effectively increases the intraocular pressure in patients with ocular hypotony after vitreoretinal surgery,uveitis,or penetrating trauma. DESIGN: A prospective randomized,double-blind,placebo controlled,crossover study. METHODS: In ten patients with ocular hypotony,an ibopamine 2% solution or placebo eyedrop was administered at 8 am and frequent applanation tonometry was performed during 10 hours on 2 days,2 weeks apart. RESULTS: The mean IOP integral after administration of ibopamine was 2.4 mm Hg higher (95% CI for median difference in AUC over 480 minutes .010) compared with placebo. CONCLUSIONS: The results of the study show that an ibopamine 2% eyedrop twice a day may increase the IOP for a period of over 8 hours in patients with hypotony.

PURPOSE： To study whether topical ibopamine effectively increases the intraocular pressure in patients with ocular hypotony after vitreoretinal surgery, uveitis, or penetrating trauma. DESIGN： A prospective randomized, double-blind, placebo controlled, crossover study. METHODS： In ten patients with ocular hypotony, an ibopamine 2% solution or placebo eyedrop was administered at 8 am and frequent applanation tonometry was performed during 10 hours on 2 days, 2 weeks apart. RESULTS： The mean lOP integral after administration of ibopamine was 2. 4 mm Hg higher （95% CI for median difference in AUC over 480 minutes . 010） compared with placebo. CONCLUSIONS： The results of the study show that an ibopamine 2% eyedrop twice a day may increase the IOP for a period of over 8 hours in patients with hypotony.